- Ph.D. University of Hamburg, Germany
I am interested in a group of plant proteins characterized by a "coiled-coil" structural motif. Coiled-coil proteins are typically involved in forming fibers and scaffolds in cells and help organize the shape, substructures, and movement of organelles within cells. In humans, mutations in coiled-coil proteins have been implemented in diseases such as cancer, muscular dystrophy, premature aging, and neurological defects. I am studying this group of proteins in plants to understand their role in an organism that does not possess muscle or nerve cells (where most long coiled-coil structures are found and studied in animals).
The group of proteins that I am particularly interested in is the chloroplast coiled-coil proteins. Chloroplasts are photosynthetic organelles that are thought to have evolved from endosymbiotic prokaryotes. However, most prokaryotes do not contain long coiled-coil proteins of the type we find in eukaryotic cells. Therefore, their import into chloroplasts is intriguing and suggests that they may have played a crucial role in the evolution of early endosymbionts into the highly structured photosynthetic organelles we find today. The study of these proteins should provide further insight into chloroplast structure and function as well as the relationship between the organelle and the host cell.
- Xu, X., Rose, A., and Meier, I. (2007). NUA activities at the plant nuclear pore. Plant Signaling and Behavior 2: 553-555.
- Xu, X., Rose, A., Muthuswamy, S., Jeong, S.Y., Venkatakrishnan, S., and Meier, I. (2007). NUCLEAR-PORE ANCHOR, the Arabidopsis homolog of Tpr/Mlp1/Mlp2/Megator, is involved in mRNA export, SUMO homeostasis and the regulation of flowering time via FLOWERING LOCUS C. Plant Cell 19: 1537-1548.
- Contributor to: Merchant et al. (2007). The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science 318: 245-250.
- Rose, A. (2007) Open mitosis: nuclear envelope dynamics. In: Verma, D.P.S., and Hong, Z. (eds.), Cell Division Control in Plants, Springer-Verlag, Heidelberg. Plant Cell Monogr. 9: 207-230.
- Rose, A., Stahlberg, E.A., and Meier, I. (2007) Genome-wide identification and comparative analysis of coiled-coil proteins. Scalable Computing: Practice and Experience 8: 167-171.
Title: Associate Professor , Plant Molecular Biology
Department: Department of Biology
Email address: Email me
Phone: (828) 262-7395