Dr Nathan Mowa

Type: 
Faculty
Position: 
Associate Professor
Department: 
Reproduction
Office: 
Rankin North 219
Phone: 
828-262-2676

Chishimba Nathan Mowa, MVM, PhD

Ph.D, Veterinary Anatomy; Hokkaido University, Graduate School of Veterinary Medicine, Sapporo, Japan; 2001
Master of Veterinary Medicine (MVM); Glasgow University, School of Veterinary Medicine, Glasgow, Scotland; 1994
Bachelor of Veterinary Medicine (equivalent of DVM), University of Zambia, School of Veterinary Medicine, Lusaka, Zambia; 1989

Fax (828) 262-2127

Professional experience:

  • 2005-present: Assistant Professor and Faculty Fellow for Diversity, Department of Biology, Appalachian State University.
  • 2004-2005: Research Instructor, Department of Neurobiology, NEOUCOM, Rootstown, OH.
  • 2001-2003: Postdoctoral Fellow, Neurobiology, Northeastern Ohio Universities College of Medicine (NEOUCOM), Rootstown, OH.
  • 1994-1996: Lecturer, Veterinary Anatomy, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia.
  • 1991-1994: Staff Development Fellow, Veterinary Anatomy, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia.
  • 1989-1991: Veterinary Surgeon, Chibote Group of Companies, Lusaka, Zambia.

Honors:

  • 2007: Offered a scholarship and admission to the Marine Biological Laboratory Frontiers in Reproduction 6-week intensive training, Woodshole, MA, U.S.A.
  • 2004: Travel grant (12th International Congress of Histochemistry and Cytochemistry, San Diego, California, July 24-28, 2004).
  • 2004: Vector Laboratories Young Investigator Award (12th International Congress of Histochemistry and Cytochemistry, San Diego, California, July 24-28, 2004).
  • 1996: Recipient of Munbusho Scholarship for PhD in Veterinary Anatomy (Offered by the Ministry of Education of the government of Japan).
  • 1993: Scholarship for M.V.M. degree (Overseas Development Agency of The British Government).
  • 1983: Undergraduate Scholarship for Veterinary Medicine studies by the government of the Republic of Zambia.

Professional memberships and committees:

  • Member, Histochemical Society
  • Committee assignment, Publication Committee, Histochemical Society
  • Member, Anatomical Association of Southern Africa

Community outreach:

  • Founder and Program Director, AppalSEED Academy (science enrichment program for minority and home school high students in Northwestern North Carolina), funded by Burroughs Welcome Fund and North Carolina Committee on Dropout Prevention Program.
  • President, Association of Zambian Adventists in North America (2005-2008)
  • Director, Boone Pathfinder Nursing Home Music (Orchestra) Ministry, Boone, NC
  • Board member, Ohio Education Board of the SDA, Mount Vernon, Ohio (2005)
  • Board member, Mayfair Junior Academy, Green, Ohio (2003-2005)

University service:

  • Co-founder and Advisor: AppalSAUS (science networking for minority students at Appalachian State University).
  • Advisor: African Students Association, Appalachian State University (2006~2008).
  • Training Officer: Institutional Animal Care and Use Committee (IACUC), Appalachian State University (2006~2008)
  • Member: Institutional Animal Care and Use Committee (IACUC), Appalachian State University (2005~)
  • Search Committees membership: Faculty Fellows (May, Dec, 2006; Jan, Feb 2007), Biology Lectureship (2006), Physiologist (2007); Biology Education faculty (September 2008~); Dean, College of Arts and Sciences (August 2008~).
  • Member: Faculty Fellow Advisory Board on Diversity, Appalachian State University (2005~)
  • Member: Appalachian State University McNair Grant Task Force (2005)

Manuscript and grant reviews:

  • Journal of Histochemistry and Cytochemistry
  • Journal of Neurobiology
  • Reproduction and Fertility
  • European Journal of Histochemistry
  • PEPTIDE
  • Adhoc Grant Reviewer for National Science Foundation (NSF).
  • Reviewer, North Carolina Space Program

Seminars and presentations:

  • Microvascular Remodeling in the cervix during pregnancy, March 1, 2007, Wake Forest School of Medicine, Comparative Medicine Clinical Research Center, Winston Salem, NC
  • Cervical ripening: Potential Role of Vascular Endothelial Growth Factor, January 11, 2006, North Carolina A & T State University, Department of Biology, Greensboro, NC
  • Just how are babies born, June 17, 2004, NEOUCOM, Program organized by the Diversity Office for summa Health Akron Schools 8th Graders, Rootstown, Ohio.
  • Cervical ripening: The role of microvascular remodeling, sensory nerve factors and estrogen, March 1, 2004, NEOUCOM, Department of Physiology Dr. Norman F. Paradise Memorial Lecture Series, Rootstown, Ohio
  • Role of estrogen in penile growth, April 14, 2003, Hokkaido University Medical School, Department of Gynecology and Obstetrics, Sapporo, Japan
  • Role of nerves in cervical ripening, April 10, 2003, Hokkaido University Medical School, Department of Gynecology and Obstetrics, Sapporo, Japan

Teaching:

  • Human Physiology Lecture: Upper level (Seniors and Juniors): Appalachian State University (Spring 2007-present)
  • Human Endocrinology Lecture: Upper level (Seniors and Juniors) and Graduate Students: Appalachian State University (Fall 2006-present)
  • Human Physiology Laboratory (Writing intensive): Upper level (Seniors and Juniors): Appalachian State University (Fall and Spring, 2005-present)
  • Tutoring First year Medical Students in Problem-Based Learning (Case Studies): NEOUCOM (2005)

Research:

Our research interest broadly involves the role of sex steroid hormones (particularly estrogen) and their interaction with vascular factors in male and female reproductive events. Our first area of interest involves the study of the labor process, specifically the process of cervical remodeling or "ripening". Our goal is to elucidate changes and mechanisms associated with, and regulating local cervical microvascular events during pregnancy and their impact on cervical remodeling. Our gene of interest is VEGF and its receptors, KDR and Flt-1.
>Our second area of interest involves the role of estrogen in penile development. In 2001, we accidentally found evidence of estrogen receptors (ER), and, later, synthesis, in an unlikely male reproductive organ, the penis. The expression of ER and aromatase, are strongly expressed during the perinatal stage, suggesting a role for estrogen during penile development. We are interested in understanding: 1) the relationship/interaction between estrogen and the "traditional" penile sex hormone, androgen, 2) mechanisms underlying estrogen action during penile development by characterizing the profile of estrogen-regulated genes in various penile cell subpopulations during development, 3) the effects of foods rich in dietary estrogens on penile development.
Characterization, using RT PCR, of VEGF in the cervix (C).
Figure 1: Characterization, using RT PCR, of VEGF in the cervix (C). Two VEGF-A splice variants, VEGF-120 and 164, were identified in the cervix in late (day 20) pregnancy with VEGF 164 being the predominant variant. The lung (L) and penis (P) of adult male rats, which predominantly express VEGF-188 and 164, respectively, were used as positive control tissues. The cDNA bands on the gel were identified, based on their molecular weight, after which they were isolated, sequenced and blasted, in order to further confirm their identity. Bp= base pair. GAPDH gene was used as a normalizer. Mowa et al J. Histochem Cytochem 2004.
field transverse sections of ER mRNA in rat neonatal penis
Figure 2: Bright - (Left) and dark (right) - field transverse sections of ER mRNA in rat neonatal penis, as revealed by in situ hybridization. U, uretha; ps, penis spongisus; pc, penis corpus. Jesmin et al 2002 ENDOCRIN

Selected publications:

CN MOWA, T Lee, S Jesmin, S Usip, H Fokkenson, R Papka 2008 Genome-wide scan of VEGF-regulated genes in uterine cervix of pregnant rats (accepted, Reproductive Biology and Endocrinology).

CN MOWA, Hoch R, Montavon CL, Jesmin S, Hindman G, Hou G 2008 Estrogen enhances wound healing in the penis of rats. Biomedical Research, October Vol 29, Number 5.

S Jesmin, S Maeda, CN MOWA, S Zaedi, H Togashi, SH Prodhan, T Yamaguchi, M Yoshioka, I Sakuma, T Miyauchi, N Kato 2007 Antagonism of endothelin action normalizes altered levels of VEGF and its signaling in the brain of stroke-prone spontaneously hypertensive rat. Eur J Pharmacol. 2007 Nov 28;574(2-3):158-71. Epub 2007 Jul 21.

S Jesmin, S Zaedi, N Shimojo, M Lemitsu, K Masuzawa, N Yamaguchi, CN MOWA, S Maeda, Y Hattori, T Miyauchi 2007 Endothelin Antagonism Normalizes VEGF Signaling and Cardiac Function in STZ-Induced Diabetic Rat Hearts. Am J Physiol Endocrinol Metab Apr 292:E1030-40.

K Aizawa, M Lemitsu, S Maeda, S Jesmin, T Otsuki, CN MOWA, T Miyauchi, N Mesaki 2007 Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle of rats. Am J Physiol Endocrinol Metab Feb 292: E577-84.

CN MOWA, S Jesmin, T Miyauchi 2006 The penis: a new target and source of estrogen in male reproduction. Histol Histopathol. Jan 21 (1):53-67 Review.

S Jesmin, S Zaedi, S Maeda, CN MOWA, I Sakuma, T Miyauchi 2006 Reversal of Elevated Cardiac Expression of TGFβ1 and Endothelin-1 Levels at the Insulin-Resistant Stage of OLETF Diabetic Rats by a Long-Acting Calcium Channel Blocker. Exp Biol Med (Maywood) 231: 907-12.

RE Papka, M Workley, S Usip, CN MOWA, J Fahrenkrug 2006 Expression of pituitary adenylate cyclase activating peptide in the uterine cervix, lumbosacral dorsal root ganglia and spinal cord of rats during pregnancy. Peptides 27: 743-52.

CN MOWA, S Jesmin, I Sakuma, H Togashi, M Yoshioka, Y Hattori, S Usip, R Papka 2004 Characterization of vascular endothelial growth factor (VEGF) in the uterine cervix over pregnancy: effects of denervation and implications for cervical ripening. J Histochem Cytochem 52: 1665-74.

S JESMIN, H Togashi, CN MOWA, K Ueno, T Yamaguchi, M Yoshioka, I Sakuma, A Kitabatake 2004 Regional cerebral blood flow and VEGF/Akt/NO signaling are disrupted in the frontal cortex of juvenile male SHRSP: possible implication for cerebrovascular abnormalities in attention-deficit/hyperactivity disorder. Brain Res 1030: 172-82.

S JESMIN, H Togashi, I Sakuma, CN MOWA, K Ueno, T Yamaguchi, M Yoshioka, A. Kitabatake 2004 Gonadal hormones and frontocortical expression of vascular endothelial growth factor in male stroke-prone, spontaneously hypertensive rats, a model for attention-deficit/hyperactivity disorder. Endocrinology 145: 4330-4343.

S JESMIN, CN MOWA, I Sakuma, N Matsuda, H Togashi, M Yoshioka, Y Hattori, A Kitabatake 2004 Aromatase is abundantly expressed by neonatal rat penis but downregulated in adulthood. J Mol Endocrinol 33: 343-59.

CN MOWA, S Usip, M Storey-Workley, R Amann, R Papka 2003 Substance P increase in uterine cervix-related ganglia (L6-S1 DRG) and decreases in cervix during pregnancy in rats. Peptides 5: 761-771.

CN MOWA, S Usip, J Collins, M Storey-Workley, KM Hargreaves, RE Papka 2003 The effects of pregnancy and estrogen on the expression of calcitonin gene-related peptide (CGRP) in uterine cervix, dorsal root ganglia and spinal cord. Peptides 8: 1163-1174.

S JESMIN, Y Hattori, I Sakuma, M Liu, CN MOWA, A Kitabatake 2003 Estrogen Deprivation and Replacement Modulate Cerebral Capillary Density With Vascular Expression of Angiogenic Molecules in Middle-Aged Female Rats. J Cerebral Blood Flow and Metab 23: 181-189.

S JESMIN, CN MOWA, N Matsuda, I Sakuma, Y Hattori, A Kitabatake 2002 Evidence for a potential role of estrogen in the penis: Detection of estrogen receptor alpha and beta mRNA and protein. Endocrinology 143: 4764-4774.

S JESMIN, I Sakuma, Y Hattori, CN MOWA, A Kitabatake 2002 Role of ANG II in coronary capillary angiogenesis at the insulin-resistant stage of a NIDDM rat model. A J Physiolog Heart Circ Physiol 283 (4): H1387-97.

CN MOWA, T Iwanaga 2001 Expression of oestrogen receptor-alpha and beta mRNAs in the male reproductive organ of the rats as revealed by in situ hybridization. J Mol Endocrinol 26: 165-174.

CN MOWA, T Iwanaga 2000 Differential distribution of oestrogen receptor-alpha and beta mRNAs in the female reproductive organ of the rats as revealed by in situ hybridization. J Endocrinol 165: 59-66.

CN MOWA, T Iwanaga 2000 Developmental changes of oestrogen receptor-alpha and beta mRNAs in the female reproductive organ of the rats—an analysis by in situ hybridization. J Endocrinol 167: 363-369.

H YANASE, CN MOWA, N Inagaki, S Seino, T Iwanaga 1998 Cellular distribution of sulfonylurea receptor 2 mRNA in the ovary and testis of rats. Biomedical Res 19: 199-204.

CN MOWA, D Hogg 1997 Ultrasonographic apparearance of bovine fetal fore-stomach. Zambia J Vet Sci 1: 3-5.

Book chapters and reviews:

CN MOWA, S. Jesmin, T. Miyauchi 2006 The penis: a new target and source of estrogen in male reproduction Histolo Histopathol 21: 53-67 (Invited Review).

CN MOWA, RE Papka 2002 The Genital Sensory System. In Encyclopedia of Neuroscience, eds George Adelman and Barry Smith, third edition (available on CD-ROM) (Invited Review).

RE PAPKA, CN MOWA 2003 Estrogen receptors in the spinal cord, sensory ganglia and pelvic autonomic ganglia. International Rev Cytol 231: 91-127 (Invited Review).

CN MOWA, R.E. Papka 2004 The role of sensory neurons in cervical ripening: effects of estrogen and neuropeptides. J Histochem Cytochem 52: 1249.

Abstracts:

Newell A, Thompson M, MOWA CN. VEGF mRNA levels are up regulated by lipopolyssacharide in the cervix of pregnant mice. FASEB meeting, San Diego, CA (April 2008).

Subrina Jesmin , Chishimba N Mowa, Newell A, Sehel Zaedi, Nobutake Shimojo, Takashi Miyauchi. Endothelin-A receptor antagonist normalizes altered cardiac function and VEGF expression in diabetic rats. FASEB meeting, Washington DC (April 2007).

MOWA CN, Montavon CL, Jesmin S, Hindman GN, Habiyambere MB, Hou G Estrogen Enhances Penile Healing and VEGF Expression in Rats. FASEB meeting, Washington DC (April 2007).

Subrina Jesmin, Chishimba N MOWA, Thompson M, Sohel Zaedi, Takashi Miyauchi Endothelin Antagonism Reverses Upregulated Renin-Angiotensin System in the hypertrophied Heart of Stroke Prone Spontaneously Hypertensive Rat (SHR-SP), not in SHR. FASEB meeting, Washington DC (April 2007).

Subrina Jesmin, Chishimba N MOWA, Habiyambere MB, Sohel Zaedi, Nobutake Shimojo, Naoto Yamaguchi, Takashi Miyauchi, Satoshi Gando Chronological expression of Endothelin-1 and TNF-α in Acute Liver Injury and its amelioration by PAR2 Blockade in a septic Rat Model. FASEB meeting, Washington DC (April 2007).

CN MOWA, T Li, HG Folkesson, S Jesmin, E Johnson, M Lopez, S Usip, D Smith, RE Papka Blockage of VEGF in the cervix of pregnant rats alters neuropeptide signaling pathways. Society for Neuroscience convention, Atlanta, Georgia, October 14-18, 2006.

CN MOWA, T Li, HG Folkesson, S Jesmin, E Johnson, M Lopez, S Usip, D Smith, RE Papka Silencing or blockage of VEGF in the cervix of pregnant rats down regulates levels of oxytocin. The Seventh Joint Meeting of The Histochemical Society and The Japan Society of Histochemistry and Cytochemistry, held under the auspices of the International Federation of Societies for Histochemistry and Cytochemistry: August 23-27, 2006, Hawai'i.

CN MOWA, T Li, H Folkesson, M Lopez, S Jesmin, S Usip, R Papka, D Smith Micellar nanocontainer polymer, pluronic block co-polymer, delivers locally-confined VEGF siRNA to the cervix of pregnant rat. FASEB Experimental Biology 2006 meeting, San Francisco April 1-5, 2006.

CN MOWA, T Li, H Folkesson, M Lopez, S Jesmin, S Usip, R Papka, D Smith Genome-wide delineation of VEGF-related genes in the cervix of pregnant rat reveals unexpected candidates. FASEB Experimental Biology 2006 meeting, San Francisco April 1-5, 2006.

S JESMIN, CN MOWA, Sohel Zaedi, Takashi Miyauchi Endothelin antagonism ameliorates cardiac dysfunction, decreases VEGF signaling and normalizes coronary collateral development in early diabetic heart. FASEB Experimental Biology 2006 meeting, San Francisco April 1-5, 2006.

S JESMIN, CN MOWA, Takashi Miyauchi Antagonism of Endothelin Action Reverses Neurovascular Remodeling in SHRSP Brain. FASEB Experimental Biology 2006 meeting, San Francisco April 1-5, 2006.

CN MOWA, S Jesmin, S Zaedi, I Sakuma, Y Hattori, T Miyauchi Estrogen receptor-α and -β are equally involved in the cerebral VEGF/AKT/NO pathway and cerebral angiogenesis in female mice. Joint meeting of The Histochemical Society and Society for Histochemistry, Noordwijkerhout, The Netherlands, 27-30 April 2005.

CN MOWA, S Usip, M Workley, J Fahrenkrug, RE Papka Expression of PACAP in the cervix, cervix-related sensory neurons and spinal cord of rats during pregnancy. Joint meeting of The Histochemical Society and Society for Histochemistry, Noordwijkerhout, The Netherlands, 27-30 April 2005.

S JESMIN, CN MOWA, S Zaedi, I Sakuma, Y Hattori, T Miyauchi Deletion of estrogen receptor a alters cardiac VEGF/AKT/NO pathway and coronary angiogenesis more than estrogen receptor β. Joint meeting of The Histochemical Society and Society for Histochemistry, Noordwijkerhout, The Netherlands, 27-30 April 2005.

CN MOWA, S Jesmin, J Hafemeister, S Usip, I Sakuma, RE Papka Denervation of pelvic nerves alters expression of cytokines in the rat cervix at parturition. Society for Neuroscience convention, San Diego, California, October 23-27, 2004.

S JESMIN, H Togashi, CN MOWA, K Ueno, T Yamaguchi, I Sakuma, M Yoshioka Disrupted VEGF/Akt/NO signaling in the frontal cortex of an animal model for attention-deficit/hyperactivity disorder. Society for Neuroscience convention, San Diego, California, October 23-27, 2004.

CN MOWA, S Jesmin, I. Sakuma, Y Hattori, S Usip, RE Papka Denervation of uterine cervix-related sensory nerves down-regulates levels of VEGF in the rat cervix at parturition. 12th International Congress of Histochemistry and Cytochemistry, San Diego, California, July 24-28, 2004.

S JESMIN, I Sakuma, H Togashi, CN MOWA, K Ueno, Y Taku, M Yoshioka, A Kitabatake Disruption of VEGF Signaling Pathway in Frontal Cortex of Juvenile Male SHRSP: Possible Implications for Cerebrovascular Abnormalities in Attention-Deficit/Hyperactivity Disorder. The 68th Annual Scientific Meeting of the Japanese Circulation Society, Tokyo, Japan, March 27-29, 2004.

S JESMIN, I Sakuma, CN MOWA, H Togashi, M Yoshioka, Y Hattori, A Kitabatake, T Miyauchi Long-term Endothelin Antagonism Reverses the Hypertension-induced Neurovascular Remodeling in the Frontal Cortex of SHR-SP. The 68th Annual Scientific Meeting of the Japanese Circulation Society, Tokyo, Japan, March 27-29, 2004.

S JESMIN, H Togashi, I Sakuma, CN MOWA, K Ueno, T Yamaguchi, M Yoshioka, A Kitabatake Disruption of VEGF-NO Signaling Pathway in Frontal Cortex of Juvenile Male SHRSP: Possible Implication for Cerebrovascular Abnormalities in Attention-Deficit/Hyperactivity Disorder. 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide. Nara, Japan, May 24-28, 2004

CN MOWA, S Usip, MS Workley, R Papka Progesterone receptor is expressed in spinal neurons and is regulated by estrogen. Society for Neuroscience convention, New Orleans, Louisiana, 8-12th November 2003.

CN MOWA, S Jesmin, H Togashi, Y Hattori, R Papka, A Kitabatake VEGF and its receptors (KDR and Flt-1) in the cervix are up-regulated during pregnancy. 194th Meeting of the Society for Endocrinology, royal College of Surgeons, London, 3-5th November 2003.

S JESMIN, H Togashi, I Sakuma, K Ueno, M Yoshioka, CN MOWA, A Kitabatake Dihydrotestosterone downregulates VEGF and its receptor in the frontal cortex of male SHRSP: an implication for the pathogenesis of attention deficit/hyperactivity disorder. Society for Neuroscience convention, New Orleans, Louisiana, 8-12th November 2003.

S JESMIN, CN MOWA, I Sakuma, H Togashi, Y Hattori, A Kitabatake Aromatase is abundantly expressed in neonatal rat penis but down-regulated in adulthood. 194th Meeting of the Society for Endocrinology, royal College of Surgeons, London, 3-5th November 2003.

S JESMIN, CN MOWA, A Salah-eldin, Y Hattori, A Kitabatake Onset of insulin-resistant stage in a Type II diabetic rat model is associated with diminished levels of vascular endothelial growth factor (VEGF) and its receptors (KDR and Flt-1) in the penis: implications in the pathogenesis of erectile dysfunction in diabetes. 194th Meeting of the Society for Endocrinology, royal College of Surgeons, London, 3-5th November 2003.

S JESMIN, I Sakuma, CN MOWA, H Togashi, Ken-ichi Ueno, M Yoshioka, Y Hattori, A Kitabatake, T Miyauchi. Progressive up-regulation of endothelin-1 and later down-regulation of VEGF/KDR/eNOS pathway in the brain may underlie the stroke susceptibility of the spontaneously hypertensive stroke-prone rats. 8th International Conference on endothelin, Tsukuba International Congress Center, Tsukuba, Japan, November, 2003.

S JESMIN, I Sakuma, CN MOWA, H Togashi, M Yoshioka, Y Hattori, A Kitabatake, T Miyauchi Long-term endothelin antagonism reverses the hypertension-induced neurovascular remodeling in the frontal cortex of SHRSP: reversal of upregulated VEGF/KDR/eNOS signaling pathway by endothelin antagonism. 8th International Conference on endothelin, Tsukuba International Congress Center, Tsukuba, Japan, November, 2003.

S JESMIN, I Sakuma, CN MOWA, H Togashi, M Yoshioka, Y Hattori, A Kitabatake, T Miyauchi. Long-term endothelin antagonism normalizes the increase in expression of ET-A receptors and ECE without affecting ET-B receptor expression in the frontal cortex of SHRSP. 8th International Conference on endothelin, Tsukuba International Congress Center, Tsukuba, Japan, November, 2003.

CN MOWA, S Usip, T Voneida, K Hargreaves, R Amann, R Papka. Substance P and calcitonin-gene related peptide change in dorsal root ganglion and uterine cervix during pregnancy and parturition. Society for Neuroscience convention, Orlando, Florida, November 2002.

S JESMIN, I Sakuma, Y Hattori, CN MOWA, S Nawate, T Makino, T Soma, K Nagai Ovariectomy reduces and estrogen replacement recovers capillary density, expressions of angiogenic factors and the related receptors in the brain of the middle-aged female rats. American Heart Association 74th scientific session, Anaheim, USA November 2001.


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